German Title: Modellierung und Computersimulation des Tumorwachstums und der Tumorantwort auf Strahlentherapie

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Translation of abstract (English)

In radiotherapy, total dose and time-dose patterns are currently chosen according to the clinical expertise of the radiation oncologist. To aid radiation oncologists in the treatment planning process, it is important to quantitatively assess tumor response to irradiation. The objective of this work is to devise a cellular radiobiological model and to develop three-dimensional simulation methods that allow simulation of tumors with clinically relevant sizes. Simulations of unperturbed tumor proliferation are compared to corresponding experimental growth curves in vivo. The most important radiobiological parameters are identified and their influence on tumor growth and tumor response to irradiation is quantified. Total doses needed by conventional and accelerated fractionation schemes for tumor control are given for different radiobiological parameters, such as cell cycle time, growth fraction and radiosensitivity.