Persistent Identifier
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doi:10.11588/data/P9JEPG |
Publication Date
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2022-12-02 |
Title
| Performance of Covid-19 antigen rapid diagnostic tests for self-testing compared with antigen testing by professionals and molecular tests: A systematic review and meta-analysis [Research Data] |
Author
| Katzenschlager, Stephan (Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany) - ORCID: 0000-0003-4977-7999
Brümmer, Lukas E. (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany) - ORCID: 0000-0002-8812-7975
Schmitz, Stephani (Department of Developmental Biology, Erasmus Medical Center, Rotterdam, Netherlands) - ORCID: 0000-0003-1188-2750
Tolle, Hannah (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany)
Manten, Katharina (Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany)
Gaeddert, Mary (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany) - ORCID: 0000-0002-6713-3495
Erdmann, Christian (FH Muenster University of Applied Sciences, Muenster, Germany) - ORCID: 0000-0003-0159-128X
Lindner, Andreas (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Hum-boldt- Universität zu Berlin, and Berlin Institute of Health; Institute of Tropical Medicine and International Health, Berlin, Germany) - ORCID: 0000-0001-5768-5109
Tobian, Frank (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany)
Grilli, Maurizio (Library, University Medical Center Mannheim, Mannheim, Germany) - ORCID: 0000-0001-7649-7242
Pollock, Nira R. (Department of Laboratory Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America) - ORCID: 0000-0002-6396-2915
Mace, Aurélien (FIND, Geneva, Switzerland) - ORCID: 0000-0002-3282-1650
Erkosar, Berra (FIND, Geneva, Switzerland) - ORCID: 0000-0003-1152-6772
Carmona, Sergio (FIND, Geneva, Switzerland) - ORCID: 0000-0002-6792-4748
Ongarello, Stefano (FIND, Geneva, Switzerland) - ORCID: 0000-0002-0032-0691
Johnson, Cheryl C. (Global HIV, Hepatitis and STIs Programmes, World Health Organization, Geneva, Switzer-land) - ORCID: 0000-0001-5499-5523
Sacks, Jilian A. (Department of Epidemic and Pandemic Preparedness and Prevention, World Health Organi-zation, Geneva, Switzerland) - ORCID: 0000-0003-4815-4693
Denkinger, Claudia M. (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany) - ORCID: 0000-0002-7216-7067
Yerlikaya, Seda (Division of Infectious Disease and Tropical Medicine, Center for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany) |
Point of Contact
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Katzenschlager, Stephan (Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany) |
Description
| Objectives Self-testing is an effective tool to bridge the testing gap for a number of infectious diseas-es; however, its performance using SARS-CoV-2 antigen-detection rapid diagnostic tests (Ag-RDTs) has not been systematically reviewed. We evaluated the accuracy of COVID-19 self-testing and/or self-sampling using Ag-RDTs to inform WHO guideline development. Methods: We searched multiple databases for articles evaluating the accuracy of COVID-19 self-testing or self-sampling through November 19th, 2021. Cohen’s kappa was estimated to as-sess concordance between self-testing/self-sampling and solely professional-use Ag-RDT results. Meta-analysis was performed to obtain pooled performance estimates compared to molecular testing. The QUADAS-2 and GRADE tools were used to evaluate quality and cer-tainty of evidence. Results: Of 12,946 publications, 19 were eligible; two reported on self-testing, while 17 studies as-sessed self-sampling only. Risk of bias was low (28.1%). Overall concordance with profes-sional-use Ag-RDTs (n=5) was high (kappa 0.92 [95% confidence interval (CI) 0.89 to 0.95]). Overall pooled sensitivity of Ag-RDT testing using self-testing/self-sampling was 72.0% (95% CI 62.4 to 80.0). Conclusion: COVID-19 self-testing/self-sampling exhibits reasonable performance and high concordance with professional-use Ag-RDTs. This suggest that self-sampling, at a minimum, can be offered as part of COVID-19 testing strategies, despite high heterogeneity among studies and the paucity of data. (2023-01-21) |
Subject
| Medicine, Health and Life Sciences |
Keyword
| SARS-CoV-2
Ag-RDT
antigen testing
systematic review
self testing |