Persistent Identifier
|
doi:10.11588/data/D2O0JZ |
Publication Date
|
2023-04-12 |
Title
| Primary Somatosensory Cortex Bidirectionally Modulates Sensory Gain and Nociceptive Behavior in a Layer-Specific Manner [Research Data] |
Subtitle
| Electrophysiology data, Figure data |
Author
| Ziegler, Katharina (Medical Biophysics, Institute for Physiology and Pathophysiology, Heidelberg University)
Folkard, Ross (Medical Biophysics, Institute for Physiology and Pathophysiology, Heidelberg University)
Gonzalez, Antonio (Medical Biophysics, Institute for Physiology and Pathophysiology, Heidelberg University)
Burghardt, Jan (Medical Biophysics, Institute for Physiology and Pathophysiology, Heidelberg University)
Antharvedi-Goda, Sailaja (Medical Biophysics, Institute for Physiology and Pathophysiology, Heidelberg University)
Martín-Cortecero, Jesús (Medical Biophysics, Institute for Physiology and Pathophysiology, Heidelberg University) - ORCID: https://orcid.org/0000-0002-9350-6267
Isaías-Camacho, Emilio (Medical Biophysics, Institute for Physiology and Pathophysiology, Heidelberg University)
Kaushalya, Sanjeev (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA)
Tan, Linette Liqi (Institute for Pharmacology, Heidelberg University, Germany)
Kuner, Thomas (Institute for Anatomy and Cell Biology, Heidelberg University, Germany) - ORCID: https://orcid.org/0000-0003-1896-9031
Acuna, Claudio (Chica and Heinz Schaller Research Group, Institute for Anatomy and Cell Biology, Heidelberg University, Germany)
Kuner, Rohini (Institute for Pharmacology, Heidelberg University, Germany) - ORCID: https://orcid.org/0000-0002-3333-9129
Mease, Rebecca
Groh, Alexander (Medical Biophysics, Institute for Physiology and Pathophysiology, Heidelberg University) - ORCID: https://orcid.org/0000-0002-5308-5971 |
Point of Contact
|
Use email button above to contact.
Groh, Alexander (Medical Biophysics, Institute for Physiology and Pathophysiology, Heidelberg University)
Mease, Rebecca |
Description
| This dataset contains electrophysiological and behavioral data and codes underlying the figures in Ziegler, K., Folkard, R., Gonzalez, A.J. et al. Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner. Nat Commun 14, 2999 (2023). https://doi.org/10.1038/s41467-023-38798-7
Abstract:
The primary somatosensory cortex (S1) is a hub for body sensation of both innocuous and noxious signals, yet its role in somatosensation versus pain is debated. Despite known contributions of S1 to sensory gain modulation, its causal involvement in subjective sensory experiences remains elusive. Here, in mouse S1, we reveal the involvement of cortical output neurons in layers 5 (L5) and 6 (L6) in the perception of innocuous and noxious somatosensory signals. We find that L6 activation can drive aversive hypersensitivity and spontaneous nocifensive behavior. Linking behavior to neuronal mechanisms, we find that L6 enhances thalamic somatosensory responses, and in parallel, strongly suppresses L5 neurons. Directly suppressing L5 reproduced the pronociceptive phenotype induced by L6 activation, suggesting an anti-nociceptive function for L5 output. Indeed, L5 activation reduced sensory sensitivity and reversed inflammatory allodynia. Together, these findings reveal a layer-specific and bidirectional role for S1 in modulating subjective sensory experiences. |
Subject
| Medicine, Health and Life Sciences |
Keyword
| Primary somatosensory cortex
Cortical output pathways
Layer 5
Layer 6
Gain control
Nociception
Antinociception
Optogenetics
Electrophysiology
Behavior |
Topic Classification
| Neuroscience |
Related Publication
| Ziegler, K., Folkard, R., Gonzalez, A.J. et al. Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner. Nat Commun 14, 2999 (2023). doi: 10.1038/s41467-023-38798-7 https://doi.org/10.1038/s41467-023-38798-7 |
Notes
| Inventory of the dataset: Ziegler et al Source Data MainFile.xlsx
The dataset contains:
1. Behavioral data: Ziegler et al Source Data MainFile.xlsx
2. In vitro ephys data: Ziegler et al Source Data MainFile.xlsx
3. In vivo ephys data, Readme.txt and codes: Ziegler_et_al_in_vivo_ephys.zip
4. Heat Map data and code: HeatMapData.zip
|
Funding Information
| DFG: SFB1158
DFG: GR3757-3-1 |
Software
| Matlab, Version: 2018a, 2022a
Kilosort, Version: 2.5
R Studio, Version: 4.2.0
Phy
Microsoft Excel, Version: 2019 |
Related Material
| https://github.com/GrohLab/Ziegler_et_al_2023 |