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Cellular Immune Responses and Immune Escape Mechanisms in Breast Cancer: Determinants of Immunotherapy

Domschke, Christoph ; Schneeweiss, Andreas ; Stefanovic, Stefan ; Wallwiener, Markus ; Heil, Joerg ; Rom, Joachim ; Sohn, Christof ; Beckhove, Philipp ; Schuetz, Florian

In: Breast Care, 11 (2016), Nr. 2. pp. 102-107. ISSN 1661-3791

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Official URL: https://doi.org/10.1159/000446061
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Abstract

More recently, immunotherapy has emerged as a novel potentially effective therapeutic option also for solid malignancies such as breast cancer (BC). Relevant approaches, however, are determined by the 2 main elements of cancer immunoediting - the elimination of nascent transformed cells by immunosurveillance on the one hand and tumor immune escape on the other hand. Correspondingly, we here review the role of the various cellular immune players within the host-protective system and dissect the mechanisms of immune evasion leading to tumor progression. If the immune balance of disseminated BC cell dormancy (equilibrium phase) is lost, distant metastatic relapse may occur. The relevant cellular antitumor responses and translational immunotherapeutic options will also be discussed in terms of clinical benefit and future directions in BC management.

Document type: Article
Journal or Publication Title: Breast Care
Volume: 11
Number: 2
Publisher: S. Karger
Date Deposited: 04 Sep 2019 09:24
Date: 2016
ISSN: 1661-3791
Page Range: pp. 102-107
Faculties / Institutes: Medizinische Fakultät Heidelberg > Universitäts-Frauenklinik
DDC-classification: 610 Medical sciences Medicine
Additional Information: Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz bzw. Nationallizenz frei zugänglich. This publication is freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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