Directly to content
  1. Publishing |
  2. Search |
  3. Browse |
  4. Recent items rss |
  5. Open Access |
  6. Jur. Issues |
  7. DeutschClear Cookie - decide language by browser settings

Repeatability and reproducibility of cerebral 23Na imaging in healthy subjects

Meyer, Melissa M. ; Haneder, Stefan ; Konstandin, Simon ; Budjan, Johannes ; Morelli, John N. ; Schad, Lothar R. ; Kerl, Hans U. ; Schoenberg, Stefan O. ; Kabbasch, Christoph

In: BMC Medical Imaging, 19 (2019), Nr. 26. pp. 1-7. ISSN 1471-2342

[thumbnail of 12880_2019_Article_324.pdf]
Preview
PDF, English - main document
Download (1MB) | Lizenz: Creative Commons LizenzvertragRepeatability and reproducibility of cerebral 23Na imaging in healthy subjects by Meyer, Melissa M. ; Haneder, Stefan ; Konstandin, Simon ; Budjan, Johannes ; Morelli, John N. ; Schad, Lothar R. ; Kerl, Hans U. ; Schoenberg, Stefan O. ; Kabbasch, Christoph underlies the terms of Creative Commons Attribution 4.0

Citation of documents: Please do not cite the URL that is displayed in your browser location input, instead use the DOI, URN or the persistent URL below, as we can guarantee their long-time accessibility.

Abstract

Abstract Background Initial reports of 23Na magnetic resonance imaging (MRI) date back to the 1970s. However, methodological challenges of the technique hampered its widespread adoption for many years. Recent technical developments have overcome some of these limitations and have led to more optimal conditions for 23Na-MR imaging. In order to serve as a reliable tool for the assessment of clinical stroke or brain tumor patients, we investigated the repeatability and reproducibility of cerebral sodium (23Na) imaging in healthy subjects. Methods In this prospective, IRB approved study 12 consecutive healthy volunteers (8 female, age 31 ± 8.3) underwent three cerebral 23Na-MRI examinations at 3.0 T (TimTrio, Siemens Healthineers) distributed between two separate visits with an 8 day interval. For each scan a T1w MP-RAGE sequence for anatomical referencing and a 3D-density-adapted, radial GRE-sequence for 23Na-imaging were acquired using a dual-tuned (23Na/1H) head-coil. On 1 day, these scans were repeated consecutively; on the other day, the scans were performed once. 23Na-sequences were reconstructed according to the MP-RAGE sequence, allowing direct cross-referencing of ROIs. Circular ROIs were placed in predetermined anatomic regions: gray and white matter (GM, WM), head of the caudate nucleus (HCN), pons, and cerebellum. External 23Na-reference phantoms were used to calculate the tissue sodium content. Results Excellent correlation was found between repeated measurements on the same day (r2 = 0.94), as well as on a different day (r2 = 0.86). No significant differences were found based on laterality other than in the HCN (63.1 vs. 58.7 mmol/kg WW on the right (p = 0.01)). Pronounced inter-individual differences were identified in all anatomic regions. Moderate to good correlation (0.310 to 0.701) was found between the readers. Conclusion Our study has shown that intra-individual 23Na-concentrations in healthy subjects do not significantly differ after repeated scans on the same day and a pre-set time interval. This confirms the repeatability and reproducibility of cerebral 23Na-imaging. However, with manual ROI placement in predetermined anatomic landmarks, fluctuations in 23Na-concentrations can be observed.

Document type: Article
Journal or Publication Title: BMC Medical Imaging
Volume: 19
Number: 26
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 05 Jun 2019 11:31
Date: 2019
ISSN: 1471-2342
Page Range: pp. 1-7
Faculties / Institutes: Medizinische Fakultät Mannheim > Institut für Klinische Radiologie
Medizinische Fakultät Mannheim > Neurologische Klinik
DDC-classification: 610 Medical sciences Medicine
Uncontrolled Keywords: 23Na (sodium) imaging, Oncologic imaging, Cerebral magnetic resonance imaging
About | FAQ | Contact | Imprint |
OA-LogoDINI certificate 2013Logo der Open-Archives-Initiative